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Similar content being viewed by others Introduction Epigenetic regulation of gene expression refers to chromatin-based mechanisms that do not introduce changes in the DNA sequence per se and is not necessarily heritable
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Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions
Zhang Y, Roh YJ, Han S-J et al (2020) Role of selenoproteins in redox regulation of signaling and the antioxidant system: a review
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